Specialty Cell Attachment
6+ Unique Surfaces for Preferential Cell Attachment
True cell attachment is very challenging. The scientists at Implant Surfaces control the electrical, chemical and bonding properties of the implant surface to elicit the desired immune response and trigger differentiation into the desired cell type. Through more than a decade of research combining physics, chemistry, biochemistry and vacuum technology, Implant Surfaces has discovered the proper surface morphologies and charge structures that attract specific cells. Every cell type needs a different surface to maximize cell attachment while minimizing fibroblast encapsulation or inappropriate cell bonding.
While titanium is reasonably biocompatible within the body, and certainly more biocompatible than PEEK and related polymers, the targeted cells for attachment each seek a deeper pattern of surface and charge to preferentially attach. Fibroblasts between bone cells and the implant can lead to potential gaps, infections, and loosening.
Photo: osteoblasts (stained) with direct on-growth to IntimateBondᵀᴹ coated PEEK (Tan). Bare PEEK with Fibroblasts (white) providing direct interference to osteoblast on-growth.
IntimateBondᵀᴹ Endothelial
Encourage immediate and complete attachment of cardiovascular endothelial cells to the stent to reduce restenosis. In testing, delivered >4X the restenosis performance target.
IntimateBond™ Periodontal Ligament Fibroblasts
IntimateBond™ Gingival Fibroblasts
Add IntimateBond™ Osteoblast
Yes, each cell type requires a different nanotopology to encourage maximum cell attachment for fixation and healing and to discourage future micro infections and related consequences.
IntimateBond™ Super-Hydrophilic Surface
Super-Hydrophilic Spiky Surface
- Less than 5º contact angle!
- Virtually unmeasurable.
- The surface is superwetting.
Our source “Spiky” surface develops the maximum surface area for drug confinement and elution, sensor sensitivity and improved catalysis from a much smaller footprint.
